Reduction of azides to amines without touching benzyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, trityl and tetrahydropyranyl ether protecting groups, C-C double and triple bond, as well as aromatic bromide and nitr...Reduction of azides to amines without touching benzyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, trityl and tetrahydropyranyl ether protecting groups, C-C double and triple bond, as well as aromatic bromide and nitrile functional groups, was achieved using sodium amalgam as a reducing reagent in methanol at temperature from -40℃ to room temperature. However, ester group was reduced under this condition.展开更多
基金Project supported by the National Natural Science Foundation of China （No. 20132030） and the Science and Technology Commission of Shanghai Municipality （No.02JC14032）.
文摘Reduction of azides to amines without touching benzyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, trityl and tetrahydropyranyl ether protecting groups, C-C double and triple bond, as well as aromatic bromide and nitrile functional groups, was achieved using sodium amalgam as a reducing reagent in methanol at temperature from -40℃ to room temperature. However, ester group was reduced under this condition.
