本文通过查阅中国知网(CNKI)、PubMed及相关参考书目,对目前心血管疾病常用中药注射液及其涉及中药有效组分的相关文献进行归纳及分析。文章所载中药注射液有川芎嗪注射液、丹参酮IIA磺酸钠注射液等5种中药注射液,其主要成分多数源自单...本文通过查阅中国知网(CNKI)、PubMed及相关参考书目,对目前心血管疾病常用中药注射液及其涉及中药有效组分的相关文献进行归纳及分析。文章所载中药注射液有川芎嗪注射液、丹参酮IIA磺酸钠注射液等5种中药注射液,其主要成分多数源自单味中药;中药中有效组分被提取作为中药注射液主要成分是趋势,占比80%;以上中药注射液不仅仅适用于某个中医证型,在相关心血管疾病中多有应用;涉及中药有丹参、川芎等,有效组分类型有皂苷和黄酮类等;多具有保护缺血再灌注损伤、抗炎、抗氧化、抗血栓形成等药理作用。本文为防治心血管疾病提供依据。China Knowledge Network (CNKI), PubMed and relevant bibliographies were consulted to summarize and analyze the current commonly-used traditional Chinese medicine injections (TCMIs) for cardiovascular diseases and their related literature involving the active components of traditional Chinese medicines. In this paper, there are 5 types of TCMIs, including ligustrazine injection, tanshinone IIA sodium sulfonate injection etc. The majority are derived from single-flavored Chinese medicines. It is a trend that the effective components of Chinese medicines are extracted to be the main ingredients of Chinese medicine injections, which accounts for 80% of the total. The above Chinese medicine injections are not only applicable to a certain TCM type, but also to the relevant cardiovascular diseases, in which they can be used in a variety of ways. Involving Chinese medicines such as Salvia miltiorrhiza and Rhizoma Ligustici Chuanxiong, etc., and the types of active components include saponins and flavonoids, etc. Most of them have the pharmacological effects of protection against ischemia-reperfusion injury, anti-inflammation, antioxidation and anti-thrombosis. This article can provide the basis of prevention and treatment of cardiovascular diseases.展开更多
原发性高血压病(Essential Hypertension, EH)作为一种全球性的慢性疾病,其发病率逐年上升,已成为心血管疾病的主要危险因素之一,严重影响人民生活质量与生命健康水平。EH患者需长期口服西药来控制血压,但临床中西药存在副作用较多,对...原发性高血压病(Essential Hypertension, EH)作为一种全球性的慢性疾病,其发病率逐年上升,已成为心血管疾病的主要危险因素之一,严重影响人民生活质量与生命健康水平。EH患者需长期口服西药来控制血压,但临床中西药存在副作用较多,对肝肾功能影响较大等弊端,且有诸多禁忌症,导致远期治疗效果差,血压控制不理想。中医药治疗原发性高血压通过辨证论治的方法,主张标本兼顾、缓急同治,具有不良反应少、远期效果平稳、更具个体化等优点。近年来,天麻钩藤饮在防治EH领域展现出较高的应用价值并取得了较为明显的临床效果。该方剂具有平肝熄风、补益肝肾、清热安神等功效,其有效成分众多,可通过多环节、多途径、多靶点干预EH,与当前复杂性疾病治疗的新概念相契合。临床实践证明,天麻钩藤饮加减联用它法或西药治疗可起到协同增效作用。研究还发现,该方剂可以通过调节血管张力、抗氧化应激、抗炎、抑制肾素–血管紧张素–醛固酮系统、调节神经系统功能来发挥效用。本文主要从理论基础、临床研究、作用机制等方面对天麻钩藤饮治疗EH进行探讨总结,以求为今后临床治疗EH开拓思路。As a global chronic disease, the incidence of essential hypertension (EH) is increasing year by year, and it has become one of the major risk factors for cardiovascular diseases, which seriously affects people’s quality of life and life and health level. EH patients need long-term oral western drugs to control blood pressure, but western drugs in clinic have the disadvantages of more side effects, greater impact on liver and kidney function, and many contraindications, resulting in poor long-term therapeutic effects and unsatisfactory blood pressure control. The treatment of essential hypertension with Chinese medicine is based on the method of evidence-based therapy, which advocates the balancing of symptoms and root causes, and the simultaneous treatment of slow and urgent conditions, and has the advantages of fewer adverse effects, stable long-term effects, and more individualization. In recent years, Tianma Hook Teng Drink has shown high application value and achieved more obvious clinical effects in the field of EH prevention and treatment. The formula has the efficacy of calming the liver and extinguishing wind, tonifying the liver and kidneys, clearing heat and tranquilizing the mind, and it has numerous active ingredients that can intervene in EH through multiple links, pathways, and targets, which is in line with the current new concept of complex disease treatment. Clinical practice has proved that the combination of Tianma Hook Teng Drink with its method or western medicine can play a synergistic effect. It was also found that the formula could be effective by regulating vascular tone, anti-oxidative stress, anti-inflammation, inhibiting the renin-angiotensin-aldosterone system, and modulating nervous system function. This article mainly discusses and summarizes the treatment of EH with Tianma Hookteng Drink from the aspects of theoretical foundation, clinical research, and mechanism of action, in order to develop ideas for the future clinical treatment of EH.展开更多
文摘本文通过查阅中国知网(CNKI)、PubMed及相关参考书目,对目前心血管疾病常用中药注射液及其涉及中药有效组分的相关文献进行归纳及分析。文章所载中药注射液有川芎嗪注射液、丹参酮IIA磺酸钠注射液等5种中药注射液,其主要成分多数源自单味中药;中药中有效组分被提取作为中药注射液主要成分是趋势,占比80%;以上中药注射液不仅仅适用于某个中医证型,在相关心血管疾病中多有应用;涉及中药有丹参、川芎等,有效组分类型有皂苷和黄酮类等;多具有保护缺血再灌注损伤、抗炎、抗氧化、抗血栓形成等药理作用。本文为防治心血管疾病提供依据。China Knowledge Network (CNKI), PubMed and relevant bibliographies were consulted to summarize and analyze the current commonly-used traditional Chinese medicine injections (TCMIs) for cardiovascular diseases and their related literature involving the active components of traditional Chinese medicines. In this paper, there are 5 types of TCMIs, including ligustrazine injection, tanshinone IIA sodium sulfonate injection etc. The majority are derived from single-flavored Chinese medicines. It is a trend that the effective components of Chinese medicines are extracted to be the main ingredients of Chinese medicine injections, which accounts for 80% of the total. The above Chinese medicine injections are not only applicable to a certain TCM type, but also to the relevant cardiovascular diseases, in which they can be used in a variety of ways. Involving Chinese medicines such as Salvia miltiorrhiza and Rhizoma Ligustici Chuanxiong, etc., and the types of active components include saponins and flavonoids, etc. Most of them have the pharmacological effects of protection against ischemia-reperfusion injury, anti-inflammation, antioxidation and anti-thrombosis. This article can provide the basis of prevention and treatment of cardiovascular diseases.
文摘原发性高血压病(Essential Hypertension, EH)作为一种全球性的慢性疾病,其发病率逐年上升,已成为心血管疾病的主要危险因素之一,严重影响人民生活质量与生命健康水平。EH患者需长期口服西药来控制血压,但临床中西药存在副作用较多,对肝肾功能影响较大等弊端,且有诸多禁忌症,导致远期治疗效果差,血压控制不理想。中医药治疗原发性高血压通过辨证论治的方法,主张标本兼顾、缓急同治,具有不良反应少、远期效果平稳、更具个体化等优点。近年来,天麻钩藤饮在防治EH领域展现出较高的应用价值并取得了较为明显的临床效果。该方剂具有平肝熄风、补益肝肾、清热安神等功效,其有效成分众多,可通过多环节、多途径、多靶点干预EH,与当前复杂性疾病治疗的新概念相契合。临床实践证明,天麻钩藤饮加减联用它法或西药治疗可起到协同增效作用。研究还发现,该方剂可以通过调节血管张力、抗氧化应激、抗炎、抑制肾素–血管紧张素–醛固酮系统、调节神经系统功能来发挥效用。本文主要从理论基础、临床研究、作用机制等方面对天麻钩藤饮治疗EH进行探讨总结,以求为今后临床治疗EH开拓思路。As a global chronic disease, the incidence of essential hypertension (EH) is increasing year by year, and it has become one of the major risk factors for cardiovascular diseases, which seriously affects people’s quality of life and life and health level. EH patients need long-term oral western drugs to control blood pressure, but western drugs in clinic have the disadvantages of more side effects, greater impact on liver and kidney function, and many contraindications, resulting in poor long-term therapeutic effects and unsatisfactory blood pressure control. The treatment of essential hypertension with Chinese medicine is based on the method of evidence-based therapy, which advocates the balancing of symptoms and root causes, and the simultaneous treatment of slow and urgent conditions, and has the advantages of fewer adverse effects, stable long-term effects, and more individualization. In recent years, Tianma Hook Teng Drink has shown high application value and achieved more obvious clinical effects in the field of EH prevention and treatment. The formula has the efficacy of calming the liver and extinguishing wind, tonifying the liver and kidneys, clearing heat and tranquilizing the mind, and it has numerous active ingredients that can intervene in EH through multiple links, pathways, and targets, which is in line with the current new concept of complex disease treatment. Clinical practice has proved that the combination of Tianma Hook Teng Drink with its method or western medicine can play a synergistic effect. It was also found that the formula could be effective by regulating vascular tone, anti-oxidative stress, anti-inflammation, inhibiting the renin-angiotensin-aldosterone system, and modulating nervous system function. This article mainly discusses and summarizes the treatment of EH with Tianma Hookteng Drink from the aspects of theoretical foundation, clinical research, and mechanism of action, in order to develop ideas for the future clinical treatment of EH.
