Objective. To investigate whether laparoscopy can be considered as adequate and reliable as standard laparotomy in predicting optimal cytoreduction (RT ≤ .1 cm) in patients with advanced ovarian cancer. Methods. From...Objective. To investigate whether laparoscopy can be considered as adequate and reliable as standard laparotomy in predicting optimal cytoreduction (RT ≤ .1 cm) in patients with advanced ovarian cancer. Methods. From March to November 2003, 95 patients with suspected advanced ovarian or peritoneal cancer have been evaluated. Thirty- one cases were excluded due to an anesthesiological class of risk ASA III- IV (51.6% ) and for the presence of a large size mass reaching the xiphoid (48.4% ). Sixty- four patients completed the study. All patients were submitted to preoperative clinico- radiological evaluation and then to both laparoscopy and standard longitudinal laparotomy, sequentially. Some specific preoperatively defined parameters were analyzed during each procedure in order to obtain the most accurate evaluation on the possibility to get an optimal cytoreduction. Results. The overall accuracy rate of laparoscopy in assessing optimal cytoreduction was 90% .The negative predictive value (NPV) of the clinical- radio- logic evaluation corresponded to 73% , whereas in no case was the judgment of unresectable disease obtained by laparoscopy changed by the laparotomic approach (NPV 100% ). On the contrary, an optimal debulking was achievable in 34 of 39 cases (87% ) selected as completely resectable by explorative laparoscopy. Conclusions. Laparoscopy can be considered super imposable to standard longitudinal laparotomy in identifying not optimally resectable advanced ovarian cancer patients.展开更多
Over representations in 20q have been reported in a number of ovarian cancers by comparative genomic hybridization. In order to study the relation of the incr eased copy number of 20q13.2 with tumor phenotype in ovari...Over representations in 20q have been reported in a number of ovarian cancers by comparative genomic hybridization. In order to study the relation of the incr eased copy number of 20q13.2 with tumor phenotype in ovarian cancer, we applied FISH on a tissue microarray. The TMA technology enables us to analyze a large nu mber of different malignancy, histology, stage and grade tumors. Overall, the fr equency of 20q13.2 alterations in epithelial ovarian cancer was 25.50%(10.74%g ains and 14.76%amplifications). There was not statistically significant differe nce between the frequencies of 20q13.2 copy number changes in different grade tu mors. The frequency of gains and amplifications increased significantly from sta ge I to stage II to stage III tumors. Our results showed strong association betw een increases 20q13.2 copies and advanced tumor stage. We concluded that genetic alterations in 20q13.2 may be of prognostic significance for stage progression of the ovarian cancer.展开更多
文摘Objective. To investigate whether laparoscopy can be considered as adequate and reliable as standard laparotomy in predicting optimal cytoreduction (RT ≤ .1 cm) in patients with advanced ovarian cancer. Methods. From March to November 2003, 95 patients with suspected advanced ovarian or peritoneal cancer have been evaluated. Thirty- one cases were excluded due to an anesthesiological class of risk ASA III- IV (51.6% ) and for the presence of a large size mass reaching the xiphoid (48.4% ). Sixty- four patients completed the study. All patients were submitted to preoperative clinico- radiological evaluation and then to both laparoscopy and standard longitudinal laparotomy, sequentially. Some specific preoperatively defined parameters were analyzed during each procedure in order to obtain the most accurate evaluation on the possibility to get an optimal cytoreduction. Results. The overall accuracy rate of laparoscopy in assessing optimal cytoreduction was 90% .The negative predictive value (NPV) of the clinical- radio- logic evaluation corresponded to 73% , whereas in no case was the judgment of unresectable disease obtained by laparoscopy changed by the laparotomic approach (NPV 100% ). On the contrary, an optimal debulking was achievable in 34 of 39 cases (87% ) selected as completely resectable by explorative laparoscopy. Conclusions. Laparoscopy can be considered super imposable to standard longitudinal laparotomy in identifying not optimally resectable advanced ovarian cancer patients.
文摘Over representations in 20q have been reported in a number of ovarian cancers by comparative genomic hybridization. In order to study the relation of the incr eased copy number of 20q13.2 with tumor phenotype in ovarian cancer, we applied FISH on a tissue microarray. The TMA technology enables us to analyze a large nu mber of different malignancy, histology, stage and grade tumors. Overall, the fr equency of 20q13.2 alterations in epithelial ovarian cancer was 25.50%(10.74%g ains and 14.76%amplifications). There was not statistically significant differe nce between the frequencies of 20q13.2 copy number changes in different grade tu mors. The frequency of gains and amplifications increased significantly from sta ge I to stage II to stage III tumors. Our results showed strong association betw een increases 20q13.2 copies and advanced tumor stage. We concluded that genetic alterations in 20q13.2 may be of prognostic significance for stage progression of the ovarian cancer.
