非酒精性脂肪性肝病(NAFLD)是全球最常见的慢性肝病,其定义为肝脏脂肪富集超过肝脏重量的5%至10%。疾病的演变过程可以从脂肪蓄积开始,逐渐进展为脂肪肝炎,肝硬化,最终可能导致肝衰竭甚至肝细胞癌的发生。肥胖伴随胰岛素抵抗、2型糖尿...非酒精性脂肪性肝病(NAFLD)是全球最常见的慢性肝病,其定义为肝脏脂肪富集超过肝脏重量的5%至10%。疾病的演变过程可以从脂肪蓄积开始,逐渐进展为脂肪肝炎,肝硬化,最终可能导致肝衰竭甚至肝细胞癌的发生。肥胖伴随胰岛素抵抗、2型糖尿病、高脂血症和代谢综合征是其主要危险因素。目前,西药治疗NAFLD主要采用水飞蓟宾胶囊、多烯磷脂酰胆碱等常规药物。中医药在治疗NAFLD方面具有很大优势。本文总结概述了中药内服、中医特色疗法以及中西医结合治疗的进展,旨在为治疗NAFLD提供参考和思路。Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and is defined as an enrichment of liver fat in excess of 5 to 10 per cent of liver weight. The evolution of the disease can start with fat accumulation and progress to steatohepatitis, cirrhosis, which may eventually lead to liver failure and even hepatocellular carcinoma. Obesity accompanied by insulin resistance, type 2 diabetes mellitus, hyperlipidaemia and metabolic syndrome is its major risk factor. Currently, western medicine is mainly used in the treatment of NAFLD with conventional drugs such as silymarin capsules and polyene phosphatidylcholine. Chinese medicine has great advantages in the treatment of NAFLD. This article summarizes and outlines the progress of internal administration of Chinese medicines, characteristic therapies of Chinese medicine as well as the combination of Chinese and Western medicines, aiming to provide references and ideas for the treatment of NAFLD.展开更多
腹水是肝硬化的失代偿期最典型的临床表现,往往代表肝病终末期,若不及时干预治疗,会促使各种并发症的发生率增加,影响患者生存时间;目前西医治疗效果不理想,随着国内外学者的研究发现,中医药能够有效缩短肝硬化腹水的病程,具备独特的临...腹水是肝硬化的失代偿期最典型的临床表现,往往代表肝病终末期,若不及时干预治疗,会促使各种并发症的发生率增加,影响患者生存时间;目前西医治疗效果不理想,随着国内外学者的研究发现,中医药能够有效缩短肝硬化腹水的病程,具备独特的临床价值。本文将从病因病机、辨证论治、方药及与中药影响的信号通路等方面详细论述中医药治疗肝硬化腹水的特色和优势。Ascites is the most typical clinical manifestation of decompensated liver cirrhosis, which often represents the end-stage of liver disease, and if not intervened in time, it can contribute to an increased incidence of various complications and affect the survival time of patients. At present, the treatment effect of Western medicine is not ideal, with the research of scholars at home and abroad, traditional Chinese medicine has obvious clinical efficacy in the treatment of liver cirrhosis ascites, and has found the advantages of multiple targets and multiple pathways. This article will discuss in detail the characteristics and advantages of traditional Chinese medicine in the treatment of ascites in liver cirrhosis from the aspects of dialectic, treatment, drug compatibility and combination with modern molecular mechanisms.展开更多
文摘非酒精性脂肪性肝病(NAFLD)是全球最常见的慢性肝病,其定义为肝脏脂肪富集超过肝脏重量的5%至10%。疾病的演变过程可以从脂肪蓄积开始,逐渐进展为脂肪肝炎,肝硬化,最终可能导致肝衰竭甚至肝细胞癌的发生。肥胖伴随胰岛素抵抗、2型糖尿病、高脂血症和代谢综合征是其主要危险因素。目前,西药治疗NAFLD主要采用水飞蓟宾胶囊、多烯磷脂酰胆碱等常规药物。中医药在治疗NAFLD方面具有很大优势。本文总结概述了中药内服、中医特色疗法以及中西医结合治疗的进展,旨在为治疗NAFLD提供参考和思路。Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and is defined as an enrichment of liver fat in excess of 5 to 10 per cent of liver weight. The evolution of the disease can start with fat accumulation and progress to steatohepatitis, cirrhosis, which may eventually lead to liver failure and even hepatocellular carcinoma. Obesity accompanied by insulin resistance, type 2 diabetes mellitus, hyperlipidaemia and metabolic syndrome is its major risk factor. Currently, western medicine is mainly used in the treatment of NAFLD with conventional drugs such as silymarin capsules and polyene phosphatidylcholine. Chinese medicine has great advantages in the treatment of NAFLD. This article summarizes and outlines the progress of internal administration of Chinese medicines, characteristic therapies of Chinese medicine as well as the combination of Chinese and Western medicines, aiming to provide references and ideas for the treatment of NAFLD.
文摘腹水是肝硬化的失代偿期最典型的临床表现,往往代表肝病终末期,若不及时干预治疗,会促使各种并发症的发生率增加,影响患者生存时间;目前西医治疗效果不理想,随着国内外学者的研究发现,中医药能够有效缩短肝硬化腹水的病程,具备独特的临床价值。本文将从病因病机、辨证论治、方药及与中药影响的信号通路等方面详细论述中医药治疗肝硬化腹水的特色和优势。Ascites is the most typical clinical manifestation of decompensated liver cirrhosis, which often represents the end-stage of liver disease, and if not intervened in time, it can contribute to an increased incidence of various complications and affect the survival time of patients. At present, the treatment effect of Western medicine is not ideal, with the research of scholars at home and abroad, traditional Chinese medicine has obvious clinical efficacy in the treatment of liver cirrhosis ascites, and has found the advantages of multiple targets and multiple pathways. This article will discuss in detail the characteristics and advantages of traditional Chinese medicine in the treatment of ascites in liver cirrhosis from the aspects of dialectic, treatment, drug compatibility and combination with modern molecular mechanisms.
