摘要
目的:探究替罗非班、丁苯酞联合支架取栓术治疗超时间窗急性脑梗死患者的临床效果。方法:选择2021年1月至2023年1月本院收治的100例超时间窗急性脑梗死(ACI)患者,利用随机数字表法分为对照组(50例,采用支架取栓术治疗)与研究组(50例,采用替罗非班、丁苯酞联合支架取栓术治疗),收集患者的临床资料,并比较两组患者的临床疗效、血脂水平、凝血功能、神经功能、生活质量及不良反应的发生率。结果:与对照组相比,研究组的总有效率显著增加(P<0.05)。治疗前,两组超时间窗ACI患者的三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、D二聚体(D-D)、纤维蛋白原(FIB)、NIHSS评分及Barthel指数量表(BI)评分比较差异均不明显(P>0.05);治疗后,两组超时间窗ACI患者的TG、TC、LDL-C、FIB、D-D及NIHSS评分均降低(P<0.05),HDL-C、PT、APTT及BI评分均升高(P<0.05),且上述指标研究组改善的更为明显(P<0.05)。两组不良反应的总发生率差异不显著(P>0.05)。结论:替罗非班、丁苯酞联合支架取栓术治疗超时间窗ACI效果确切,可改善患者血脂水平、凝血功能及神经功能,并有助于提高患者的生活质量,安全性好。
AIM:To investigate the clinical effects of tirofiban and butylphthalide combined with stent thrombectomy in the treatment of patients with acute cerebral infarction in the ultra-time window.METHODS:A total of 100 patients with ACI beyond time window admitted to our hospital from January 2021 to January 2023 were randomly grouped into the control group(50 cases,treated with stent thrombectomy)and the study group(50 cases,treated with tirofiban and butylphthalide combined with stent thrombectomy),clinical data of patients were collected,and the clinical efficacy,blood lipid levels,coagulation function,neurological function,quality of life,and incidence of adverse reactions were compared between the two groups.RESULTS:Compared with the control group,the total effective rate of the study group obviously increased(P<0.05).Before treatment,there was no obvious difference between the two groups in triacylglycerol(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),highdensity lipoprotein cholesterol(HDL-C),prothrombin time(PT),activated partial thromboplastin time(APTT),D-dimer(D-D),fibrinogen(FIB),NIHSS score and Barthel index scale(BI)score of patients with ACI beyond time window(P>0.05).After treatment,the TG,TC,LDL-C,FIB,D-D,and NIHSS score of ACI patients in both groups decreased(P<0.05),while HDL-C,PT,APTT,and BI score increased(P<0.05),and the above indicators improved more obviously in the study group(P<0.05).There was no obvious difference in the total incidence of adverse reactions between the two groups(P>0.05).CONCLUSION:The combination of tirofiban and butylphthalide with stent thrombectomy in the treating ACI beyond time window has a definite effect,which can improve the blood lipid level,coagulation function and neurological function of patients,and help to improve the quality of life of patients,with good safety.
作者
涂汉明
徐国强
陈永康
TU Hanming;XU Guoqiang;CHEN Yongkang(Department of Neurology,Yongkang First People's Hospital,Jinhua 321300,Zhejiang,China)
出处
《中国临床药理学与治疗学》
北大核心
2025年第3期398-403,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
浙江省医药卫生科技计划项目(2023XY068)。
关键词
超时间窗急性脑梗死
替罗非班
丁苯酞
支架取栓术
神经功能
acute cerebral infarction beyond time window
tirofiban
butylphthalide
stent thrombectomy
neurological function
