摘要
目的探究益生菌联合枸橼酸莫沙必利治疗乙肝肝硬化合并小肠细菌过度生长的效果。方法选取2020年3月至2022年3月于井冈山市中医院就诊的67例乙肝肝硬化合并小肠细菌过度生长患者作为研究对象,按照随机数字表法分为对照组(n=33)与观察组(n=34)。对照组给予常规治疗,观察组在对照组基础上给予益生菌联合枸橼酸莫沙必利治疗。比较两组临床疗效、肝功能指标[丙氨酸转氨酶(alanine aminotransferase,ALT)、总胆红素(total bilirubin,TBIL)、天冬氨酸转氨酶(aspartate aminotransferase,AST)、肝功能Child-Pugh评分]、血清生化指标[白细胞介素-6(interleukin-6,IL-6)、内毒素、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]及小肠细菌过度生长情况。结果治疗10 d后,观察组治疗总有效率为88.24%,高于对照组的63.64%,差异有统计学意义(P<0.05)。治疗10 d后,两组血清ALT、TBIL、AST水平及肝功能Child-Pugh评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗10 d后,两组血清IL-6、内毒素、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组转阴率为70.58%,高于对照组的33.33%,差异有统计学意义(P<0.05)。结论益生菌联合枸橼酸莫沙必利治疗乙肝肝硬化合并小肠细菌过度生长的疗效显著,可明显改善患者肝脏功能及相关指标,减少血清内毒素含量,减轻机体炎症反应,改善小肠细菌过度生长状态。
Objective To explore the effect of probiotics combined with mosapride citrate in the treatment of hepatitis B cirrhosis complicated with intestinal bacterial overgrowth.Methods 67 patients with hepatitis B cirrhosis complicated with intestinal bacterial overgrowth in Jinggangshan Hospital of Traditional Chinese Medicine from March 2020 to March 2022 were selected as the study subjects,and they were randomly divided into the control group(n=33)and the observation group(n=34).The control group was given routine treatment,while the observation group was treated with probiotics combined with mosapride citrate on the basis of the control group.The clinical efficacy,liver function index(alanine aminotransferase[ALT],total bilirubin[TBIL],aspartate aminotransferase[AST],liver function Child-Pugh score),serum biochemical index(interleukin-6[IL-6],endotoxin,tumor necrosis factor-α[TNF-α])and intestinal bacterial overgrowth were compared between the two groups.Results After 10 d of treatment,the total effective rate in the observation group was 88.24%,which was higher than 63.64%in the control group,and the difference was statistically significant(P<0.05).After 10 d of treatment,serum ALT,TBIL,AST levels and liver function of Child-Pugh score of the two groups were lower than before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).After 10 d of treatment,serum IL-6,endotoxin and TNF-αlevels of the two groups were lower than before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).The negative conversion rate in the observation group was 70.58%,which was higher than 33.33%in the control group,and the difference was statistically significant(P<0.05).Conclusion The clinical efficacy of probiotics combined with mosapride citrate in the treatment of hepatitis B cirrhosis complicated with intestinal bacterial overgrowth is significant,which can significantly improve the liver function and related indexes,reduce the content of serum endotoxin and reduce the inflammatory reaction of the body,improve the overgrowth of bacteria in the small intestine.
作者
黄岗宜
高琼
刘苏春
HUANG Gangyi;GAO Qiong;LIU Suchun(Department of Outpatient Emergency,Jinggangshan Hospital of Traditional Chinese Medicine,Ji'an,Jiangxi,343600,China;Department of Internal Medicine,Jinggangshan Hospital of Traditional Chinese Medicine,Ji'an,Jiangxi,343600,China)
出处
《当代医学》
2024年第24期124-127,共4页
Contemporary Medicine
关键词
肝硬化
小肠细菌过度生长
益生菌
枸橼酸莫沙必利
Liver cirrhosis
Intestinal bacterial overgrowth
Probiotics
Mosapride citrate
