摘要
目的外阴Paget病(PDV)是一种罕见的恶性肿瘤,常被误认为是其他良性疾病。本文回顾性分析北京大学人民医院收治的外阴Paget病患者的临床特点,探讨治疗方式。方法本研究对2013年1月至2023年12月在北京大学人民医院妇科治疗的PDV患者进行回顾性分析。8例均接受手术,4例行带蒂皮瓣转移术,2例补充光动力治疗。结果5例切缘呈阳性。1例创面裂开二次手术恢复良好。8例患者随访的平均时间为53个月(13~130个月),随访期间观察到1例皮损,目前均存活,无疾病相关死亡。结论PDV病程较长,皮损范围大,恶性程度低,有远期复发倾向。应及早诊断,以避免大手术对局部外阴结构和功能破坏,可配合光动力等后续补充治疗提高治愈率。
Objective Extramammary Paget Disease of the Vulva(PDV)is a rare malignant tumor that is often mistaken for other benign conditions.This article retrospectively analyzed the clinical characteristics of patients with PDV admitted to our hospital and explores treatment methods.Methods We retrospectively analyzed PDV patients treated in the Department of Gynecology,Peking University People's Hospital from 2013 to 2023.All 8 cases underwent surgery,4 cases underwent pedicle flap transfer surgery,and 2 cases underwent photodynamic therapy.Results A total of 5 cases showed positive margins.One case of wound rupture recovered well after secondary surgery.The average follow-up time of 8 patients was 53 months(range 13~130 months),and 1 recurrence was observed during the follow-up period.Currently,all patients are alive and there are no disease-related deaths.Conclusions PDV has a long course of disease,a wide range of lesions,a low degree of malignancy and a tendency of long-term recurrence.Early diagnosis should be made to avoid damage to the structure and function of the local vulva after major surgery.The cure rate can be improved with follow-up supplementary treatment such as photodynamic treatment.The course of PDV is prolonged,with extensive skin lesions and low malignancy,but it has a tendency for long-term recurrence.Early diagnosis is crucial to avoid extensive surgery that could damage the structure and function of the vulva.Photodynamic therapy and other supplementary treatments can be used to improve the cure rate.
作者
杨莹超
张艺环
王悦
李广学
王益勤
郝娟
YANG Yingchao;ZHANG Yihuan;WANG Yue;LI Guangxue;WANG Yiqin;HAO Juan(Department of Obstetrics and Gynecology,Peking University People's Hospital,Beijing 100044,China;Department of Obstetrics and Gynecology,Tibet Autonomous Region People's Hospital,Lhasa 850010,China;Department of Plastic Surgery,Peking University People's Hospital,Beijing 100044,China)
出处
《中国妇产科临床杂志》
2025年第1期27-29,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
科技部国家重点研发计划(2016YFC1302901)。
关键词
外阴Paget病
带蒂皮瓣转移术
光动力治疗
extramammary Paget disease of the vulva
flap transfer
photodynamic therapy
