摘要
目的 探讨中药灌肠联合中药塌渍法在慢性肾衰竭(CKD3 ~5期)、皮肤瘙痒(血虚风湿瘀毒证)的临床有效性及安全性。方法 本研究采用多中心、随机对照原则,共纳入病例90例,疗程4周。根据随机表法分为对照组和试验组,各45例。对照组维持西医基础治疗,试验组为西医基础治疗加中药灌肠联合中药塌渍法治疗。观察2组治疗前后皮肤瘙痒情况、肾功能、睡眠质量,以及血常规、谷丙转氨酶、钙磷、甲状旁腺激素等指标,评估临床疗效和安全性。结果 试验组总有效率为88.8%。对照组总有效率为44.4%。治疗后试验组血红蛋白、血肌酐、尿素氮、β2微球蛋白、血磷指标改善明显。2组未出现血小板、谷丙转氨酶、血钙等安全性指标异常。结论 中药灌肠联合中药塌渍法治疗慢性肾衰竭患者皮肤瘙痒的治疗方法有效,安全性好,能有效改善患者皮肤瘙痒及肾功能。
Objective To explore the clinical effi cacy and safety of Chinese herbal enema combined with external medicinal liquid application on itch of skin(blood defi ciency,rheumatism,syndrome of stasis toxin)in patients with chronic renal failure(CRF 3-5 stage).Methods This study adopted the multicenter,randomized controlled trial principle.A total of 90 cases were enrolled,and the treatment course was 4 weeks for all cases.The selected patients were divided into the control group and the experiment group according to random number table method,with 45 cases in each group.The control group received basic Western medicine treatment,and the experiment group received basic Western medicine treatment plus Chinese herbal enema combined with external medicinal liquid application.The eff ects of itch of skin,renal function,and sleep quality before and after treatment in two groups were observed,and the levels of indicators such as blood routine,alanine aminotransferase,calcium phosphate,and parathuyroid hormone were observed.Clinical efficacy and safety were evaluated.Results The total effective rate of the experiment group was 88.8%,while that of the control group was 44.4%.After treatment,the levels of hemoglobin,creatinine,urea nitrogen,β2 microglobulin and phosphorus in the experiment group were significantly improved.There were no abnormlities in safety indicators such as platelets,glutamic-pyruvic transaminase and blood calcium in both groups.Conclusion Herbal enema combined with external medicinal liquid application is eff ective and safe in the treatment of itch of skin in patients with chronic renal failure,and can eff ectively improve pruritus and renal function in patients.
作者
徐毅
周波
罗斗前
陈方明
宋小丽
XU Yi;ZHOU Bo;LUO Douqian;CHEN Fangming;SONG Xiaoli(Department of Nephrology,Dazhou Integrated TCM&Western Medicine Hospital,Dazhou 635000,China;Department of Nephrology,Wanyuan Hospital of Traditional Chinese Medicine of Dazhou City,Dazhou 635000,China)
出处
《长春中医药大学学报》
2024年第9期986-989,共4页
Journal of Changchun University of Chinese Medicine
基金
四川省中医药管理局课题(2020LC0105)。
关键词
中药灌肠
中药塌渍法
慢性肾功能衰竭
皮肤瘙痒
临床研究
Chinese herbal enema
external medicinal liquid application
chronic renal failure
itch of skin
clinical research
