摘要
目的探讨长链非编码RNA(LncRNA)表达水平与膀胱癌患者预后的相关性。方法检索PubMed,Web of Science和China National Knowledge Infrastructure(CNKI)数据库中关于LncRNAs表达水平与膀胱癌预后相关性的文献,提取相关数据后采用STATA12.0软件进行Meta分析。结果纳入7篇文献,共计722例患者。Meta分析结果显示:LncRNAs高表达与膀胱癌患者总生存期较低存在相关性(HR=2.23,95%CI:1.64~3.04,P<0.01)。结论 LncRNAs高表达与膀胱癌的不良预后有一定的关系,有望成为潜在的判断膀胱癌预后的生物靶标。
Objective To systematically uncover the correlation between the expression level of long chain non coding RNA(LncRNA)and the prognosis of bladder cancer patients Methods Databases including PubMed,Web of Science,and China National Knowledge Infrastructure(CNKI)were searched for relevant literatures about the the correlation between the expression level of LncRNAs and the prognosis of bladder cancer.After data were extracted,a Meta-analysis was performed using STATA12.0software.Results A total of7eligible studies including722cases were acquired from the databases that met the inclusion criteria.The Meta analysis showed that high expression of LncRNAs is associated with a shorter life period in patients with bladder cancer(HR=2.23,95%CI:1.64-3.04,P<0.01).Conclusion The high expression of LncRNAs has a certain relationship with the poor prognosis of bladder cancer and is expected to be a potential biological target for predicting the prognosis of bladder cancer.
作者
夏悦昕
周世航
梁晓华
XIA Yuexin;ZHOU Shihang;LIANG Xia(Dalian Blood Center,Dalian,Liaoning 116000,China)
出处
《国际检验医学杂志》
CAS
2018年第6期696-698,702,共4页
International Journal of Laboratory Medicine
